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1 article(s) from Granzhan, Anton

Identification of optimal fluorescent probes for G-quadruplex nucleic acids through systematic exploration of mono- and distyryl dye libraries

Xiao Xie,
Michela Zuffo,
Marie-Paule Teulade-Fichou and
Anton Granzhan

Beilstein J. Org. Chem. 2019, 15, 1872–1889, doi:10.3762/bjoc.15.183

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Graphical Abstract

Figure 1: Some di- and mono-styryl dyes previously reported as fluorescent “light-up” probes for G4-DNA and R...

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Figure 2: Design of a library of di- and mono-styryl dyes. Counter-ions are omitted for the sake of clarity.

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Scheme 1: A, B) General synthesis of A) distyryl and B) mono-styryl dyes via Knoevenagel condensation route. ...

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Scheme 2: Synthesis of I3–5 and I15.

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Figure 3: Representative absorption spectra of distyryl dyes: A) 1d, B) 1ð, C) 1f, D) 1u, E) 10a and F) 12a i...

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Figure 4: Representative absorption spectra of the distyryl dyes (c = 10 µM in MeOH) demonstrating the influe...

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Figure 5: Heat map of the relative emission intensity enhancement (I/I₀) of styryl dyes and thioflavin T (ThT...

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Figure 6: Analysis of the light-up response matrix of the dyes. The average light-up factor of each dye with ...

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Figure 7: PC1 vs PC2 plot obtained from the principal component analysis of the light-up data matrix for all ...

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Figure 8: Dual-dye conformational analysis of an extended panel of 33 DNA oligonucleotides. This is performed...

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Figure 9: Selected probes featuring high fluorimetric response towards G4 structures.

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Figure 10: Photographs of solutions of A) distyryl dyes 1p and 1u; B) mono-styryl dyes 17a and 18a, in the abs...

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Published 06 Aug 2019

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